Tissue of Origin® 

The Tissue of Origin test, formally a Pathwork test, is a microarray-based gene expression test that aids in identifying challenging tumors, including metastatic, poorly differentiated, and undifferentiated cancers.  TOO is the ONLY FDA-cleared test of its type and is a Medicare-reimbursed test.

Tissue of Origin Head & Neck Test

Histological examination doesn’t always distinguish primary lung tumors from lung metastasis in patients with Head & Neck squamous cell carcinoma (SCC), since SCC is common in both sites.

The Tissue of Origin Head & Neck Test, a laboratory developed test, distinguishes between squamous cell carcinoma of the Head & Neck and squamous cell carcinoma of the lung using a 2600 gene classification model.

Head & Neck

TOO-Head and Neck Table

Tissue of Origin Head & Neck Analysis

  • When non-small cell lung is the highest SS in the Tissue of Origin Test, the Tissue of Origin Head & Neck test may be ordered at no additional charge.
  • SS range from 0 (low) to 100 (high) and sum to 100 across the two tissues, ovarian and endometrial.