Cancer Genetics advances understanding of immune response and measurement in lymphomas by combining PD-L1 expression analysis with RNA analysis

Published on: Monday, December 11th, 2017 View all Media

Study Presented at the 59th American Society of Hematology (ASH) Annual Meeting
Study focused on DLBCL (Diffuse Large B-Cell Lymphomas)

RUTHERFORD, N.J., Dec. 11, 2017 (GLOBE NEWSWIRE) — Cancer Genetics, Inc. (Nasdaq:CGIX), a leader in enabling precision medicine for oncology through molecular markers and diagnostics, today announced results of a study demonstrating the potential value of being platform-agnostic and choosing the best diagnostic modality to evaluate an important molecular biomarker, PD-L1, in DLBCL (Diffuse Large B-Cell Lymphomas). The results (abstract 1477) were presented on Sunday, December 10, 2017 at the 59th ASH Annual Meeting in Atlanta.

The study compared performance of multiple antibody clones against PD-L1 and the current standard diagnostic modality, immunohistochemistry (IHC), to an in-situ hybridization (ISH), using RNAscope®1 approach to determine the expression of PD-L1 in diffuse large B-cell lymphoma (DLBCL) cells, a particularly aggressive form of lymphoma. Although the two modalities demonstrated relative concordance related to the identification of PD-L1 expression, there were differences that indicated that RNA-ISH may be the superior approach. First, RNA-ISH appeared to be more sensitive, identifying cases of PD-L1 expression that were negative using IHC. Second, high PD-L1 expression identified by RNA-ISH, but not IHC, was highly correlated with non-germinal center B-cell subtype, gains at the PD-L1/9p24 locus (a predictor of PD-L1 inhibitor response) and demonstrated a trend toward worse overall survival. The study demonstrates that choice and integration of diagnostic modalities can provide key additional information to assist oncologists to more accurately select therapeutic options for their patients.

“Precision oncology is all about better identifying the biomarkers in a patient’s tumor that both assist in diagnosis and drive a treatment plan tailored to the patient’s cancer with the objective of obtaining an optimal clinical outcome,” said Panna Sharma, President and CEO of Cancer Genetics. “This means that companies and laboratories in precision oncology should utilize the platform or platforms that generate the best validated information to drive treatment. This study demonstrates for a particular tumor type, DLBCL, that RNA-ISH generates superior information compared to IHC alone, which has been the standard for many years. We at Cancer Genetics would like to take this approach further to the benefit of the oncology community and the patients they treat.”

Poster and Oral Presentation Title (abst 1477): Precision in PD-L1 Assessment in Diffuse Large B Cell Lymphoma: Greater Biological Insight Using in Situ Hybridization Approach
Session 622Lymphoma Biology—Non-Genetic Studies
Time/Date: Saturday, December 9, 2017, 5:30 to 7:30 p.m. EST
Presenter: Imran Siddiqi, M.D., Ph.D., University of Southern California

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1 RNAscope is a registered trademark of Advanced Cell Diagnostics


ABOUT CANCER GENETICS
Cancer Genetics, Inc. is a leader in enabling precision medicine in oncology from bench to bedside through the use of oncology biomarkers and molecular testing. CGI is developing a global footprint with locations in the US, Australia and China. We have established strong clinical research collaborations with major cancer centers such as Memorial Sloan Kettering, The Cleveland Clinic, Mayo Clinic, Keck School of Medicine at USC and the National Cancer Institute.

The Company offers a comprehensive range of laboratory services that provide critical genomic and biomarker information. Its state-of-the-art reference labs are CLIA-certified and CAP-accredited in the US and have licensure from several states including New York State.

For more information, please visit or follow CGI at:
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